Portuguese Research Center Discovers Mechanism That May Explain Greater or Less Severity of Infection – The Observer

Published

3 years ago

August 4, 2021

Portuguese Research Center Discovers Mechanism That May Explain Greater or Less Severity of Infection - The Observer

Researchers at the Institute for Health Research and Innovation (i3S) have discovered a mechanism related to T cell alteration that may explain why SARS-CoV-2 infection causes mild to severe illness in humans.

In a statement from the Institute of the University of Porto on Wednesday, it was published that researchers had discovered a mechanism that “may explain why SARS-CoV-2 infection causes mild or even asymptomatic illness some people have severe and complex illnesses in others. “

The results of the study, funded by the Research 4 Covid Initiative of the Science and Technology Foundation (FCT), were published in the Journal of Immunology, and the article was noted as a “top reader” for the September issue.

A study by researcher Salome Pinho showed that circulating T cells “exchange their glycans.” [moléculas de açúcar] especially after infection with SARS-CoV-2 “and that this change “More pronounced” in asymptomatic people than in symptomatic people…

“Thus, an immunological response is determined based on glycosylated forms of T-lymphocytes, which provides protection against the virus,” the institute assured.

The alteration of the glycosylation profile in the immune response after infection with SARS-CoV-2 “appears to be caused by an inflammatory factor present in the plasma of the individuals.”

According to researcher Salome Pinho, this specific T-cell glycosignature, more pronounced in asymptomatic patients, “can be detected at diagnosis” and represents “A new biomarker of severity and prognosis of Covid-19, as well as a new therapeutic target”…

In parallel, the research team demonstrated that asymptomatic patients have mononuclear blood cells exhibit “increased expression of a specific protein”capable of efficiently recognizing the virus and the level of expression of which in monocytes [células inflamatórias que pertencem à primeira linha de defesa] correlated with “better patient prognosis”.

Also mentioned in the paper, Ines Alves and Manuel Vicente, the first authors of the study, say it is important to emphasize that this mechanism associated with SARS-CoV-2 infection “may be related to another type of respiratory viral infections that are opening up. new opportunities for the study of other infectious diseases ”.

The role of T lymphocytes in resolving or exacerbating Covid-19, as well as the ability to provide long-term protection against re-infection with SARS-CoV-2, “remains to be fully disclosed,” notes i3S.

The investigation looked to the cooperation of the University Hospital Center of Porto and the Hospital Center Vila Nova de Gaia / Espinho.

According to the latest report from Agence France-Presse, the Covid-19 pandemic has caused at least 4,234,618 deaths worldwide out of more than 198.8 million infections with the new coronavirus.

In Portugal, 17,397 people have died and 974,203 cases have been reported since the pandemic began in March 2020, according to the General Directorate of Health.

The respiratory illness is caused by the SARS-CoV-2 coronavirus, discovered in late 2019 in Wuhan, a city in central China, and currently variants identified in countries such as the UK, India, South Africa, Brazil and Peru.

Herb Adkins

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Portuguese historical films will premiere on 29 December.

Published

1 year ago

December 20, 2022

Herb Adkins

Portuguese historical films will premiere on 29 December.

Method Media Bermuda will present the documentary FABRIC: Portuguese History in Bermuda on Thursday, December 29 at the Underwater Research Institute of Bermuda.

A spokesperson said: “Method Media is proud to bring Bermuda Fabric: Portugal History to Bermuda for its 5th and 6th showing at the Bermuda Underwater Observatory. In November and December 2019, Cloth: A Portuguese Story in Bermuda had four sold-out screenings. Now that Bermuda has reopened after the pandemic, it’s time to bring the film back for at least two screenings.

“There are tickets Ptix.bm For $ 20 – sessions at 15:30 and 18:00. Both screenings will be followed by a short Q&A session.

Director and producer Milton Raboso says, “FABRIC is a definitive account of the Portuguese community in Bermuda and its 151 years of history, but it also places Bermuda, Acors and Portugal in the world history and the events that have fueled those 151 years.

“It took more than 10 years to implement FABRIC. The film was supported by the Minister of Culture, the Government of the Azores and private donors.

“Bermuda Media Method [MMB] Created in 2011 by producer Milton Raposo. MMB has created content for a wide range of clients: Bermuda’s new hospital renovation, reinsurance, travel campaigns, international sports and more. MMB pays special attention to artistic, cultural and historical content.

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Herb Adkins

Proud web evangelist. Travel ninja. Creator. Freelance food nerd. Passionate bacon fanatic.

CRISTANO RONALDO CAN MAKE UP A GIANT IN CARIOCA AND PORTUGUESE TECHNICIAN SAYS ‘There will be room’

Published

1 year ago

December 20, 2022

Herb Adkins

CRISTANO RONALDO CAN MAKE UP A GIANT IN CARIOCA AND PORTUGUESE TECHNICIAN SAYS 'There will be room'

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Maestro de Braga is the first Portuguese in the National Symphony Orchestra of Cuba.

Published

1 year ago

December 19, 2022

Herb Adkins

Maestro de Braga is the first Portuguese in the National Symphony Orchestra of Cuba.

Maestro Filipe Cunha, Artistic Director of the Philharmonic Orchestra of Braga, has been invited to conduct the Cuban National Symphony Orchestra, as announced today.

According to a statement sent by O MINHO, “he will be the first Portuguese conductor to conduct this orchestra in its entire history.”

In addition to this orchestra, the maestro will also work with the Lyceo Mozarteum de la Habana Symphony Orchestra.

The concerts will take place on 4 and 12 March 2023 at the National Theater of Cuba in Havana.

In the words of the maestro, quoted in the statement, “these will be very beautiful concerts with difficult but very complex pieces” and therefore he feels “very motivated”.

From the very beginning, Rachmaninoff’s Piano Concerto No. 2 will be performed by an Italian pianist (Luigi Borzillo), whom the maestro wants to bring to Portugal later this year. In the same concert, Mendelshon’s First Symphony will be performed.

Then, at the second concert, in the company of the Mexican clarinetist Angel Zedillo, he will perform the Louis Sfora Concerto No. 2. In this concert, the maestro also conducts Tchaikovsky’s Fifth Symphony.

“This is an international recognition of my work. An invitation that I accept with humility and great responsibility. I was surprised to learn that I would be the first Portuguese member of the Cuban National Symphony Orchestra. This is a very great honor,” the maestro said in a statement.

“I take with me the name of the city of Braga and Portugal with all the responsibility that goes with it, and I hope to do a good job there, leaving a good image and putting on great concerts. These will be very special concerts because, in addition to performing pieces that I love, especially Rachmaninov and Tchaikovsky, I will be directing two wonderful soloists who are also my friends. It will be very beautiful,” concludes Filipe Cunha.

Herb Adkins

Proud web evangelist. Travel ninja. Creator. Freelance food nerd. Passionate bacon fanatic.