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Vaccine breakthrough could finally bring coronavirus to its knees



Vaccine breakthrough could finally bring coronavirus to its knees

Photo by Erin O’Flynn/The Daily Beast/Getty Images

com New variants and sub-variants of COVID Develop faster and faster, each of which destroys the power of the flagship. vaccineThe search continues for a new type of vaccine that works well against current and future forms of the novel coronavirus.

Now researchers at the National Institutes of Health in Maryland believe they have created a new approach to vaccine development that could lead to a longer-acting dose. As a bonus, it can also work on another coronavirusand not just the SARS-CoV-2 virus that causes COVID.

The National Institutes of Health team reported their findings in Peer reviewed study what appeared in the magazine host cell and microbe earlier this month.

The key to a potential NIH vaccine project is a part of the virus called the “spinal cochlea”. It’s a helical structure within a spike protein, which is part of the virus that helps it attach to our cells and infect them.

Many current vaccines target the spike protein. But none of them specifically target spiny snails. However, there are good reasons to focus on this particular part of the pathogen. While many regions of the spike protein tend to change a lot as the virus mutates, the same thing happens with the snail’s spine. No.

Proven method of dealing with monstrous variants of the COVID virus will not work in the US

This gives scientists “hope that an antibody that targets this region will be more durable and broadly effective,” Joshua Tan, lead scientist at the NIH group, told The Daily Beast.

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Vaccines that target and “bind” to, for example, the region of the receptor-binding domain of the spike protein may lose their effectiveness if the virus grows in that region. The great thing about spiny snails from an immunological standpoint is that they don’t mutate. At least he didn’t mutate For nowThree years of the COVID pandemic.

Therefore, a vaccine that binds to the SARS-CoV-2 snail should work for a long time. And it should also work on all other coronaviruses, which also include spinal snails – and there are dozens of them, including several such as SARS-CoV-1 and MERS, which have already increased the number of animals and caused outbreaks in humans.

To test their hypothesis, NIH researchers extracted antibodies from 19 recovered COVID patients and tested them on samples from five different coronaviruses, including SARS-CoV-2, SARS-CoV-1 and MERS. Of the 55 different antibodies, most are concentrated on parts of the virus that are prone to strong mutations. 11 targets only the snail’s spine.

But the 11 people who chose the spinal IUD did better on average with four coronaviruses. (A fifth virus, HCoV-NL63, excludes all antibodies.) The NIH team isolated the best coiled spike antibody, COV89-22, and also tested it in hamsters infected with newer Omicron sub-variants of the COVID variant. The team found that “hamsters treated with COVID-89-22 had a lower rate of disease.”

The results are promising. These results define a class of … broadly neutralizing antibodies. [coronaviruses] Aimed at the trunk of a snail,” the researchers wrote.

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The champagne hasn’t erupted yet. The NIH panel cautioned that “while these data are useful for vaccine development, we did not test the vaccines in this study and therefore cannot draw definitive conclusions about the effectiveness of coiled vaccines.”

It’s one thing to test for certain antibodies in a hamster. It is another matter to develop and test and get approval for an entirely new class of vaccines. “It’s very difficult, and most things start with good ideas failing for one reason or another,” James Lawler, an infectious disease specialist at the University of Nebraska Medical Center, told The Daily Beast.

A huge mistake that could allow COVID to overtake our vaccines

Although it turns out that antibodies against the backbone of the cochlea wide effective, it is not clear how they compare to more specific antibodies. In other words, an acne spiral injection may work against a group of different but related viruses, but it is less effective against any one virus than an injection designed specifically for that virus. “More trials are needed to evaluate whether they provide adequate protection in humans,” Tan said of cochlear and spinal antibodies.

There is a lot of work to be done before the spiral vaccine is available at Zawia Pharmacy. There are many things that can interfere with this work. Additional research may conflict with the NIH team’s findings. The new vaccine design may not work as well in humans as it does in hamsters.

A new vaccine may also be unsafe, not feasible to produce, or too expensive to be widely distributed. Barton Haynes, an immunologist at Duke University, told The Daily Beast that last year he reviewed snail-backbone vaccine projects and concluded they would be too expensive to justify the large investment. The main problem, he says, is that spiny snail antibodies are less effective and “difficult to induce” than the mother’s B cells.

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The harder the pharmaceutical industry has to work to produce a vaccine, and the more vaccine has to be packaged in a single dose to make up for the lower potency, the less economical a mass-produced vaccine will be.

Perhaps the spiral acne scam is in our future. Or maybe not. In any case, it is encouraging that scientists are gradually moving in this direction. Global Corona Virus Vaccine🇧🇷 One that could work for many years on a wide range of related viruses.

COVID, for example, is not going anywhere. And with each mutation, it risks becoming unrecognizable in modern vaccines. We need a mutagenic vaccine.

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James Webb Telescope Reveals a New View of the Pillars of Creation



Nearly 30 years ago, the Pillars of Creation stunned the world of astronomy when they were photographed by NASA’s famed Hubble Space Telescope.

Now a new generation can take a fresh look at the spectacular spectacle after the $10 billion (£7.4 billion) James Webb Hyperspace Telescope captured the same tentacles of gas and dust.

Resembling a ghostly hand, the Pillars of Creation are part of the Eagle Nebula, which lies 6,500 light-years from Earth and is known to be a source of star formation.

This week, NASA and the European Space Agency unveiled another look at Webb’s sharp eye feathers.

Bonito: Nearly 30 years ago, the Pillars of Creation stunned the world of astronomy when they were photographed by NASA’s famed Hubble Space Telescope. Now a new generation can take a fresh look at the spectacular spectacle after the $10 billion (£7.4 billion) James Webb Space Telescope captured the same tentacles of gas and dust (pictured).

Hubble took the first image of the Pillars of Creation in 1995. It provided the first evidence that stars could be born inside pillars.

What are the pillars of creation?

This is one of the most iconic space features ever captured on camera.

The Pillars of Creation was first captured by NASA’s Hubble Telescope in 1995 and re-captured in 2014.

Now, almost 30 years after we first saw the dying formation, it has been captured again by NASA’s new James Webb Super Space Telescope.

The Pillars of Creation, located 6500 light years from Earth in the constellation Serpens, are part of the Eagle Nebula.

It is known to be an important source of star formation.

Gas and dust in tentacle-like tentacles give rise to stars, including many very young, and some now photographed only a few 100,000 years old.

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In the 1995 Hubble image, blue represents oxygen, red represents sulfur, and green represents nitrogen and hydrogen.

The pillars are bathed in scorching ultraviolet light from off-screen clusters of young stars.

The winds of these stars are slowly destroying towers of gas and dust.

The most recent image was taken in the mid-infrared range, which dims the brightness of stars and captures only streams of gas and dust. It gave a new way to experience and understand amazing composition.

Webb has instruments that can see in different wavelengths of infrared light.

In October, experts published an image of the Pillars of Creation taken with the Near Infrared Camera (NIRCam) and then added an image taken with the Mid Infrared Light (MIRI) instrument.

Now they’ve stitched the images together to create a breathtaking image that shows the best of both worlds, showing bright edges of dust where young stars are just starting to form.

NIRCam shows newly formed stars in orange outside the pillars, while MRI shows layers of dust forming.

“This is one of the reasons this region is filled with stars – dust is a key component of star formation,” NASA said.

The bright red fingertips on the second column indicate active star formation, but the stars are still very young – according to NASA, they are only 100,000 years old.

It takes millions of years to fully form.

“By combining images of the iconic Pillars of Creation from two cameras aboard NASA’s James Webb Space Telescope, the cosmos is framed in infrared glory,” writes Webb’s team.

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They said it “fired up this star forming region with new details.”

When clumps of gas and dust of sufficient mass form at the poles, they begin to collapse under their own gravity, slowly heating up and eventually forming new stars.

“Newly formed stars are especially visible at the edges of the top two pillars — they’re practically visible,” Webb’s team said.

Almost everything you see in this scene is local.

The distant Universe is largely hidden from our view by the interstellar medium, consisting of rarefied interstellar gas and dust, and a thick layer of dust in our own galaxy, the Milky Way.

“As a result, stars take center stage in the Pillars of Creation web show.”

The Pillars of Creation are located in the constellation Serpens.

New Super Space Telescope: Webb (pictured) has instruments that can see multiple wavelengths of infrared light.

In October, experts released an image of the Pillars of Creation from the Near Infrared Camera (NIRCam).

Then take a picture of a mid-infrared (MIRI) device.

It houses the hot young star cluster NGC6611, visible through modest backyard telescopes, cutting through and illuminating the surrounding gas and dust, creating huge holes and hollow pillars, each a few light-years across.

A 1995 Hubble image hinted that new stars were being born inside the pillars. Due to dust clogging, the Hubble Space Telescope’s visible-light image could not look inside and prove that young stars were forming.

So NASA brought Hubble back for a second visit, allowing them to compare the two images.

Astronomers have noticed a change in the jet-like feature moving away from one of the newborn stars inside the pillars.

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Between observations, the length of the jet increased by 60 billion miles, indicating that the material in the jet was moving at about 450,000 miles per hour.

James Webb Telescope: NASA’s $10 billion telescope designed to detect light from the oldest stars and galaxies.

The James Webb Telescope has been described as a “time machine” that could help unlock the secrets of our universe.

The telescope will be used to observe the first galaxies born in the early universe more than 13.5 billion years ago, looking for the sources of stars, exoplanets and even our solar system’s moons and planets.

The huge telescope, which once cost over $7 billion (£5 billion), is believed to be the successor to the Hubble Space Telescope.

The James Webb telescope and most of his instruments are around 40 K, about minus 387 Fahrenheit (minus 233 degrees Celsius).

It is the largest and most powerful orbiting space telescope in the world, capable of looking back 100-200 million years after the Big Bang.

The infrared observatory orbiting it is about 100 times more powerful than its predecessor, the Hubble Space Telescope.

NASA prefers to think of James Webb as Hubble’s successor rather than his replacement, as the two will work together for a while.

The Hubble Telescope was launched on April 24, 1990 by the Space Shuttle Discovery from the Kennedy Space Center in Florida.

It orbits the Earth at about 17,000 miles per hour (27,300 km/h) in low Earth orbit at an altitude of about 340 miles.

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LastPass security compromised and user data exposed



LastPass segurança dados utilizadores passwords

LastPass is one of the most famous and commonly used password managers on the web. Even with some major changes, it was still a safe offering that many use on a daily basis.

The service was again criticized for another major security issue. This is the second time in a short period of time that attackers have gained access to user data yet again.

Another LastPass security flaw

In August, LastPass had major security issues. A simple attack gave access to the company's servers, from which important company information is believed to have been stolen. At the time, it was clear that there was no user data theft.

Now, months later, it is clear that much more happened in that attack. LastPass has been attacked again and this time it is known that user data has been exposed. Company disclosed that it has detected "unusual activity" on third-party cloud storage, but existing passwords remain encrypted and secure.

The attackers are known to have used information obtained in August to access "some elements" of customer information. LastPass immediately launched an investigation by hiring the security company Mandiant and the authorities were also alerted.

LastPass Security Data User Passwords

User data is open, no passwords

The company is working intensively to understand the scope of this incident and to determine exactly what information was accessed. You further warrant that while this evaluation is ongoing, LastPass products and services will continue to function without restriction.

However, LastPass encourages its users to follow the installation and setup guidelines. This includes various measuresincluding setting up two-factor authentication to access the services of this platform.

The revealed case does not leave a positive image of LastPass. This is more of a case of a security issue that occurs over a short period of time. While passwords are not disclosed or used, there is the potential for sensitive data to be accessed and used.

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Future Apple AR/VR headset system could be “xrOS”



Ilustração do headset de AR/VR da Apple

BUT Apple took another step towards launching his mixed reality headsetthe device, due to be launched next year, will combine augmented reality (AR) and virtual reality (VR) technologies.

According to information from Mark GurmanYes bloomberg, Apple has changed the name of the operating system that will ship with the device. According to anonymous sources of the journalist, the company refused old name “realityOS” and has now adopted the nomenclature “chroOS”.

The new name appears precisely to emphasize that this is a “mixed reality” device, since the abbreviation XR is often used to refer to augmented reality (augmented reality), a concept that spans both AR and VR.

As Gurman noted, while augmented reality overlays virtual graphics and information on the real world, virtual reality is a comprehensive and immersive experience for activities such as playing games and watching videos.

“xrOS” should have exclusive versions of Apple apps such as Messages this is Cards – as well as with some App Storewhere other developers can host and distribute their proprietary software.

Apple expects the mixed reality device to be its latest “great product” that hasn’t been seen in Cupertino since the device’s launch. Apple Watch (in 2015) — today one of the largest sources of profit for the company.

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