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Vaccine breakthrough could finally bring coronavirus to its knees



Vaccine breakthrough could finally bring coronavirus to its knees

Photo by Erin O’Flynn/The Daily Beast/Getty Images

com New variants and sub-variants of COVID Develop faster and faster, each of which destroys the power of the flagship. vaccineThe search continues for a new type of vaccine that works well against current and future forms of the novel coronavirus.

Now researchers at the National Institutes of Health in Maryland believe they have created a new approach to vaccine development that could lead to a longer-acting dose. As a bonus, it can also work on another coronavirusand not just the SARS-CoV-2 virus that causes COVID.

The National Institutes of Health team reported their findings in Peer reviewed study what appeared in the magazine host cell and microbe earlier this month.

The key to a potential NIH vaccine project is a part of the virus called the “spinal cochlea”. It’s a helical structure within a spike protein, which is part of the virus that helps it attach to our cells and infect them.

Many current vaccines target the spike protein. But none of them specifically target spiny snails. However, there are good reasons to focus on this particular part of the pathogen. While many regions of the spike protein tend to change a lot as the virus mutates, the same thing happens with the snail’s spine. No.

Proven method of dealing with monstrous variants of the COVID virus will not work in the US

This gives scientists “hope that an antibody that targets this region will be more durable and broadly effective,” Joshua Tan, lead scientist at the NIH group, told The Daily Beast.

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Vaccines that target and “bind” to, for example, the region of the receptor-binding domain of the spike protein may lose their effectiveness if the virus grows in that region. The great thing about spiny snails from an immunological standpoint is that they don’t mutate. At least he didn’t mutate For nowThree years of the COVID pandemic.

Therefore, a vaccine that binds to the SARS-CoV-2 snail should work for a long time. And it should also work on all other coronaviruses, which also include spinal snails – and there are dozens of them, including several such as SARS-CoV-1 and MERS, which have already increased the number of animals and caused outbreaks in humans.

To test their hypothesis, NIH researchers extracted antibodies from 19 recovered COVID patients and tested them on samples from five different coronaviruses, including SARS-CoV-2, SARS-CoV-1 and MERS. Of the 55 different antibodies, most are concentrated on parts of the virus that are prone to strong mutations. 11 targets only the snail’s spine.

But the 11 people who chose the spinal IUD did better on average with four coronaviruses. (A fifth virus, HCoV-NL63, excludes all antibodies.) The NIH team isolated the best coiled spike antibody, COV89-22, and also tested it in hamsters infected with newer Omicron sub-variants of the COVID variant. The team found that “hamsters treated with COVID-89-22 had a lower rate of disease.”

The results are promising. These results define a class of … broadly neutralizing antibodies. [coronaviruses] Aimed at the trunk of a snail,” the researchers wrote.

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The champagne hasn’t erupted yet. The NIH panel cautioned that “while these data are useful for vaccine development, we did not test the vaccines in this study and therefore cannot draw definitive conclusions about the effectiveness of coiled vaccines.”

It’s one thing to test for certain antibodies in a hamster. It is another matter to develop and test and get approval for an entirely new class of vaccines. “It’s very difficult, and most things start with good ideas failing for one reason or another,” James Lawler, an infectious disease specialist at the University of Nebraska Medical Center, told The Daily Beast.

A huge mistake that could allow COVID to overtake our vaccines

Although it turns out that antibodies against the backbone of the cochlea wide effective, it is not clear how they compare to more specific antibodies. In other words, an acne spiral injection may work against a group of different but related viruses, but it is less effective against any one virus than an injection designed specifically for that virus. “More trials are needed to evaluate whether they provide adequate protection in humans,” Tan said of cochlear and spinal antibodies.

There is a lot of work to be done before the spiral vaccine is available at Zawia Pharmacy. There are many things that can interfere with this work. Additional research may conflict with the NIH team’s findings. The new vaccine design may not work as well in humans as it does in hamsters.

A new vaccine may also be unsafe, not feasible to produce, or too expensive to be widely distributed. Barton Haynes, an immunologist at Duke University, told The Daily Beast that last year he reviewed snail-backbone vaccine projects and concluded they would be too expensive to justify the large investment. The main problem, he says, is that spiny snail antibodies are less effective and “difficult to induce” than the mother’s B cells.

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The harder the pharmaceutical industry has to work to produce a vaccine, and the more vaccine has to be packaged in a single dose to make up for the lower potency, the less economical a mass-produced vaccine will be.

Perhaps the spiral acne scam is in our future. Or maybe not. In any case, it is encouraging that scientists are gradually moving in this direction. Global Corona Virus Vaccine🇧🇷 One that could work for many years on a wide range of related viruses.

COVID, for example, is not going anywhere. And with each mutation, it risks becoming unrecognizable in modern vaccines. We need a mutagenic vaccine.

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‘My power is really low’: NASA’s Mars Insight rover prepares to launch from the Red Planet



NASA Lander InSight He has delivered what may be his last message from Mars as he embarks on a historic mission to uncover the secrets of the Red Planet’s interior.

In November, the space agency warned that the probe could be running out of time as dust continued to condense and stifle InSight’s power.

“Spacecraft power generation continues to decline as windblown dust accumulates on solar panels,” NASA said in a statement. Update November 2. “The end is expected to come in the coming weeks.”

message shared NASA The InSight Twitter account tweeted on Monday: “My power is very low so this might be the last photo I can upload. Don’t worry about me: my time here has been productive and uneventful. If I can keep talking to my mission team, I will—but I will.” Subscribe here soon. Thank you for staying with me.”

My power is very low, so this might be the last photo I can upload. But don’t worry about me: my time here has been productive and uneventful. If I can keep talking to my mission team, I will, but I’ll sign here soon. Thank you for staying with me.

— NASA InSight (@NASAInSight) December 19, 2022

A geologist robot armed with a hammer and a seismograph first reached the barren expanse of Elysium Planitia in November 2018.

Since then, she has carried out geological excavations, taking the first measurements of earthquakes with a high-tech seismometer placed right on the surface of Mars.

Last month, the solar-powered car released an update to remind us of its time in space.

“I was lucky to live on two planets. Four years ago I made it safely to the second one, much to the joy of my family at first. Thanks to my team for taking me on this journey of discovery. I hope I can be proud of you.”

According to the published mission, Insight has measured more than 1,300 seismic events since it was published, and more than 50 of them had signals clear enough for the team to extract information about their location on Mars. Results.

The probe’s data also provided detailed information about Mars’ interior, liquid core, surprisingly variable remnants beneath the surface of an extinct magnetic field, climate and seismic activity.

old for Its launch in 2018NASA Chief Scientist Jim Green said the mission was “fundamental to understanding the origins of our solar system and how it became what it is today.”

NASA will not declare the mission complete until Insight confirms the arrival of two spacecraft orbiting Mars that are relaying their information back to Earth.

In 2018, the veteran rover announced the capabilities end of his 15 year stay Sending an incomplete photo of the Valley of Perseverance.

A severe dust storm darkened the sky around the solar-powered rover, shattering the sun and leaving behind a dark image with white spots due to camera noise. The transmission is interrupted before the complete image can be transmitted.

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What’s new on February 7, 2023



OnePlus 11 5G Buds Pro 2 evento

Being very close companies, OPPO and OnePlus have decided to create a new partnership, with the latter being a pioneer in the market. It has become the representative of the best smartphones in the group, and this will be seen very soon.

Proving this, OnePlus has announced that it will have news soon. The following brand assets will be announced on February 7, 2023. We are talking about OnePlus 11 5G and Buds Pro 2.

In recent years, OnePlus has been showcasing new hardware in an attempt to find a new place in the market. The brand has not always seen its full potential, betting on mid-range or entry-level smartphones.

The situation is changing, and the novelty will go on sale in early 2023, February 7. It is on this day that the new OnePlus 11 5G will be presented with all the expected news. We definitely have the new Qualcomm Snapdragon 8 Gen 2 SoC here. There's still 16GB of storage left and 256GB of onboard storage.

OnePlus 11 5G Buds Pro 2 events

It is expected that he will receive a 6.7-inch OLED display with a resolution of 1440p and a frequency of 120 Hz. In the field of photography, we will have an important change: a 50 MP main camera, a 48 MP ultra wide-angle camera and a 32 MP telephoto lens with 2x zoom. For selfies and video calls, you'll have a 16-megapixel camera.

The photography partnership with Hasselblad will continue with OnePlus for fine-tuning and some additions. This alliance has brought important results for the best smartphones of the brand, guaranteeing the best photos in any situation.

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OnePlus 11 5G Buds Pro 2 events

In addition to the new OnePlus 11 5G, another brand new feature is also expected to arrive at the event. We're talking about the Buds Pro 2, which are solidifying an audio commitment that's becoming more of a reality. The brand promises "rich stereo quality sound with crystal clear clarity".

Stays like this marked by the beginning of February, another important novelty will enter the market. OnePlus wants to reclaim its place, and that will be the brand's bet for years to come. OnePlus 11 5G and Buds Pro 2 take the first step in this direction.

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New POCO Smartphone Seen in Certification May Debut Soon



New POCO Smartphone Seen in Certification May Debut Soon

According to information provided by Mukul Sharma, the unidentified POCO device can be identified by the model number 22127PC95I. Due to the fact that it was first seen online, the marketing name of this equipment is still a mystery.

POCO has not launched new mobile devices, including smartphones, to the market for some time now. On the other hand, several POCO smartphones such as POKO X5 and X5 Pro have been spotted on various certification sites, suggesting that the company will release these products soon. Today a new smartphone from the sub-brand xiaomi has been spotted on the BIS India website but the device does not have a name or any other details associated with it.

According to information provided by Mukul Sharma, the unidentified POCO device can be identified by the model number 22127PC95I. Due to the fact that it was first seen online, the marketing name of this equipment is still a mystery. It is possible that it will debut as a mid-range smartphone. The Bureau of Indian Standards (BIS) website, other than the model number of the smartphone, does not provide any additional information about the device. However, this seems to indicate that the product will be available in the Indian market very soon.

In other related news, POCO X5 5G has recently been seen on several certification sites including SIRIM in Malaysia, BIS in India and the US FCC. According to various sources, it is possible that this is a renamed or modified version Redmi Note 12 5Gwhich was recently released in China.

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It is supposed to be equipped screen 6.67″ AMOLED display with 120Hz refresh rate and chipset Snapdragon 4 Gen 1 inside. Can run MIUI 13 based on android 12 and have LPDDR4x RAM in addition to UFS 2.2 storage. The front camera is rumored to be 8MP while the main rear camera will be 48MP with 2MP depth. May have the ability drums 5000 mAh and 33W fast charging support.

In addition POCO X5 Pro 5G has recently been seen on various sites dedicated to certification. The battery is said to have a capacity of 5000 mAh and can charge at 67W. It will come with MIUI 14 preinstalled and will support n5, n7, n38, n41, n77 and n78 network bands. 5G.

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