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The Portuguese researcher’s discovery in New York could be a new asset in the fight against tuberculosis.



The Portuguese researcher's discovery in New York could be a new asset in the fight against tuberculosis.

The protein, “discovered” by a Portuguese researcher at the Cornell University School of Medicine in New York, could open up important new avenues in the fight against tuberculosis, which, despite the established cure, remains one of the deadliest infectious diseases. for humanity.

Before the SARS-CoV-2 virus that spread the covid-19 pandemic, the virus Mycobacterium tuberculosis – The bacteria, also known as Koch’s bacillus (after German bacteriologist Robert Koch, who discovered it), was the pathogen that caused the most deaths in the world, and by 2020 was estimated to be associated with about 1.5 million deaths. …

According to the latest World Health Organization (WHO) report on the disease, deaths from tuberculosis have increased in the past year “for the first time in more than a decade” after the global response to covid-19 “declined. years of progress. “ And even Portuguese emergency hospitals have recently seen a return of severe cases of tuberculosis, as reported just last week by infectious disease specialist Maria João Brito, who is responsible for the infectious diseases department at Dona Estefânia Hospital in Lisbon.

The identification of new, more effective treatments for the disease continues to be a priority highlighted by WHO and the recent discovery by Thiago Rodriguez Beites, published this Monday in the prestigious Scientific journal Nature Communicationscould be an important step forward.

Tuberculosis bacteria mainly infect the lungs and depend on the host’s fatty acids and cholesterol for energy to survive and reproduce. And science has already identified a bacterial enzyme that can metabolize these fatty acids in the human body: acyl-coenzyme A dehydrogenase (acyl-CoA dehydrogenase).

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“But this enzyme is part of a more complex chain that regulates its function,” explains Thiago Beites. AND The Portuguese researcher and his team at Weill Cornell Medicine discovered that there is a protein that links an enzymatic network of the type, without which acyl-CoA cannot have its normal activity. In other words, “it stops feeding on fatty acids,” and the bacteria die.which is confirmed by tests in vitro and in animal models (mice), the results of which are now published in this scientific journal, in a study already reviewed by colleagues.

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Portuguese historical films will premiere on 29 December.



Portuguese historical films will premiere on 29 December.

Method Media Bermuda will present the documentary FABRIC: Portuguese History in Bermuda on Thursday, December 29 at the Underwater Research Institute of Bermuda.

A spokesperson said: “Method Media is proud to bring Bermuda Fabric: Portugal History to Bermuda for its 5th and 6th showing at the Bermuda Underwater Observatory. In November and December 2019, Cloth: A Portuguese Story in Bermuda had four sold-out screenings. Now that Bermuda has reopened after the pandemic, it’s time to bring the film back for at least two screenings.

“There are tickets For $ 20 – sessions at 15:30 and 18:00. Both screenings will be followed by a short Q&A session.

Director and producer Milton Raboso says, “FABRIC is a definitive account of the Portuguese community in Bermuda and its 151 years of history, but it also places Bermuda, Acors and Portugal in the world history and the events that have fueled those 151 years.

“It took more than 10 years to implement FABRIC. The film was supported by the Minister of Culture, the Government of the Azores and private donors.

Bermuda Media Method [MMB] Created in 2011 by producer Milton Raposo. MMB has created content for a wide range of clients: Bermuda’s new hospital renovation, reinsurance, travel campaigns, international sports and more. MMB pays special attention to artistic, cultural and historical content.

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Maestro de Braga is the first Portuguese in the National Symphony Orchestra of Cuba.



Maestro de Braga is the first Portuguese in the National Symphony Orchestra of Cuba.

Maestro Filipe Cunha, Artistic Director of the Philharmonic Orchestra of Braga, has been invited to conduct the Cuban National Symphony Orchestra, as announced today.

According to a statement sent by O MINHO, “he will be the first Portuguese conductor to conduct this orchestra in its entire history.”

In addition to this orchestra, the maestro will also work with the Lyceo Mozarteum de la Habana Symphony Orchestra.

The concerts will take place on 4 and 12 March 2023 at the National Theater of Cuba in Havana.

In the words of the maestro, quoted in the statement, “these will be very beautiful concerts with difficult but very complex pieces” and therefore he feels “very motivated”.

From the very beginning, Rachmaninoff’s Piano Concerto No. 2 will be performed by an Italian pianist (Luigi Borzillo), whom the maestro wants to bring to Portugal later this year. In the same concert, Mendelshon’s First Symphony will be performed.

Then, at the second concert, in the company of the Mexican clarinetist Angel Zedillo, he will perform the Louis Sfora Concerto No. 2. In this concert, the maestro also conducts Tchaikovsky’s Fifth Symphony.

“This is an international recognition of my work. An invitation that I accept with humility and great responsibility. I was surprised to learn that I would be the first Portuguese member of the Cuban National Symphony Orchestra. This is a very great honor,” the maestro said in a statement.

“I take with me the name of the city of Braga and Portugal with all the responsibility that goes with it, and I hope to do a good job there, leaving a good image and putting on great concerts. These will be very special concerts because, in addition to performing pieces that I love, especially Rachmaninov and Tchaikovsky, I will be directing two wonderful soloists who are also my friends. It will be very beautiful,” concludes Filipe Cunha.

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