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Protein that delays the development of Alzheimer’s disease discovered by a group led by a Portuguese

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Protein that delays the development of Alzheimer's disease discovered by a group led by a Portuguese

A team of scientists led by Claudio Gomes of the University of Lisbon Faculty of Science (FCUL) discovered that the S100B protein acts on the tau protein, thereby delaying the progression of Alzheimer’s disease.

The study was conducted by scientists from I3S – Institute for Health Research and Innovation, University of Porto, University of Lille in France, University of Hohenheim, Germany, and University of Texas, USA, and published in the scientific journal Nature Communications.

They concluded that the S100B protein acts on the tau protein, “toxic deposition in the brain is associated with various types of dementia and the flare-up phase of Alzheimer’s,” he said in a statement to FCUL about work done with cultures. bacterial cells that have been genetically engineered to express human proteins produced in the laboratory.

According to the study authors, this finding has implications for Alzheimer’s disease, given that “the onset of cognitive symptoms and dementia are associated with damage caused by aggregates of the tau protein and the spread of pathology to multiple areas of the brain.”

“This study reveals a new biological defense mechanism that is relevant in the early stages of the disease, which becomes ineffective over time due to the growing accumulation of toxic aggregates in the brain,” said Claudio Gomez, who told Luce that the “hypothesis” on which he “worked” his team, is that the protein “S100B” will perform protective functions against protein aggregation in the phase before the onset of symptoms of the disease, but in which “changes are already taking place in brain cells” (neurons) and “accumulation of deposits” of proteins “as part of early inflammatory response. “

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The researchers hope that understanding the functioning and protective action of proteins such as S100B will lead to the development of drugs with “therapeutic potential” that act in a similar way.

According to the OECD Health Outlook 2017 report, Alzheimer’s disease is the most common form of dementia that causes progressive and irreversible damage to certain cognitive functions. Portugal is the fourth country with the most diagnosed cases of dementia.

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Every Portuguese wastes 183 kg of food a year, and this is “inconceivable”.

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Every Portuguese wastes 183 kg of food a year, and this is "inconceivable".

President of the Portuguese Federation of Food Banks Against Hunger Isabelle Jonet considers food waste unacceptable and absurd, as every Portuguese wastes 183 kg of food a year.

As World Food Loss and Waste Awareness Day is celebrated, speaking at a conference on the subject in Lisbon, the official recalled statistics released by the National Statistical Institute and said the situation was “worse than expected.”

The data, official and published for the first time, refers to 2020 and shows that 1.89 million tons of food was wasted in Portugal this year, so each Portuguese wasted an average of 183.6 kilograms of food.

INE statistics show that families spend the most. The figures show that over 1.2 million tons of food was wasted by families this year, followed by catering with over 237 thousand tons, trade and distribution with 214 thousand tons, primary production with over 101 thousand tons and food . industry, about 61 thousand tons.

“We buy too much, we buy bad, we let it go bad. It is unacceptable that a third of what is produced ends up in the trash,” the official said, speaking at a debate organized by the United Movement Against Waste.

Ana Cristina Carrola of the Portuguese Environmental Protection Agency (APA), who also took part in the debate, stressed that the average amount of waste per year per inhabitant in the European Union is 173 kg, less than the 183 kg that is thrown away by the Portuguese.

“This is unthinkable in our day,” he lamented.

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Thanks to goals from Evanilson and Pepe, Porto beat Braga in Portuguese; Sporting wins too

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Thanks to goals from Evanilson and Pepe, Porto beat Braga in Portuguese;  Sporting wins too



Evanilson scored four goals in eight matches in the 2022/23 Portuguese Liga (Photo: MIGUEL RIOPA/AFP)

Photo: Lance!

After the draw in the last round Portuguese Championship, Porto won again. This Friday, the defending champions thrashed Braga 4-1 at the Dragau Stadium. Goals came from Evanilson, Eustaquio, Pepe and Galeno. Defender Pepe, against, got to the opponent.

Ex-Fluminense Evanilson opened the scoring in the 32nd minute of the opening stage. Eustaquio tried to make a cross and the Brazilian forward appeared on the second post to prop up his chest. Two minutes later, Pepe filed Eustaquio, who sent the ball into an empty net.

In the final stage, the Portuguese-Brazilian defender Pepe tried to cut off a low cross, but sent him into his own net. Pepe, the former Gremio who assisted, got it from Taremi after a beautiful move that extended the game in the 18th minute. In addition, the Brazilian Galeno closed the account in the north of Portugal.

– I am very happy to score again and, above all, for this victory. A match we knew would be difficult, against a strong opponent who was in good sequence, but in which we managed to impose our rhythm and win three points in front of our fans. Now it’s time to rest and get back to work, already thinking about the next challenge, which is also very important for us, – said Evanilson after the match.

SPORTING TOO WINS

Another great player to take the field this Friday is Sporting CP. In Lisbon, on José de Alvalade, the Lions beat Gil Vicente 3-1. For Rubén Amorim’s side, Morita, Pote Gonçalves and Rocinha scored. Fran Navarro scored in stoppage time.



Sporting CP are the vice-leaders of Portugal (Photo: PATRICIA DE MELO MOREIRA / AFP)

Sporting CP are the vice-leaders of Portugal (Photo: PATRICIA DE MELO MOREIRA / AFP)

Photo: Lance!

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Portuguese tennis player Gonçalo Oliveira in the doubles final of the Lisbon Belém Open

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Portuguese coach praises the development of women's handball after the Iberian duel

Oliveira and Kolar defeated France’s Manuel Guinard and Venezuela’s Luis David Martínez in the semi-finals for first place in the series, in straight sets with partial scores of 6-1 and 6-2 after 58 minutes of play.

In the title match, they will take on the Ukrainian duo of Vladislav Manafov and Oleg Prikhodko, who eliminated Jivan Nedunchezhyan of India and Christopher Rungkat of Indonesia 6-4 and 6-2 in the semi-finals.

For the 27-year-old Portuguese tennis player, this will be his 31st doubles final at the ATP Challenger Tour and third at the Lisboa Belém Open after reaching the final in 2017 with compatriot Frederico Gil and champion in 2020 with Dominican Roberto Cid Subervi.

In singles, Italian Marco Cecchinato, semi-finalist of Roland Garros in 2018, beat Spaniard Carlos Taberner 7-6 (7-2) and 6-4, scheduling a meeting in the semi-final with the “Reserve” Kazakh Timofey Skatov, responsible for eliminating Frenchman Benoit Pera, in three matches, with a score of 6-4, 2-6 and 7-5.

The other semi-final of the Lisbon tournament will be discussed between Austrian Filip Mizolich, who defeated Giulio Zeppieri 6-4 today, and Frenchman Luca van Assche, the executioner of compatriot Alexander Müller, who finished seventh. parts 6-4 and 7-5.

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