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Protein that delays the development of Alzheimer’s disease discovered by a group led by a Portuguese



Protein that delays the development of Alzheimer's disease discovered by a group led by a Portuguese

A team of scientists led by Claudio Gomes of the University of Lisbon Faculty of Science (FCUL) discovered that the S100B protein acts on the tau protein, thereby delaying the progression of Alzheimer’s disease.

The study was conducted by scientists from I3S – Institute for Health Research and Innovation, University of Porto, University of Lille in France, University of Hohenheim, Germany, and University of Texas, USA, and published in the scientific journal Nature Communications.

They concluded that the S100B protein acts on the tau protein, “toxic deposition in the brain is associated with various types of dementia and the flare-up phase of Alzheimer’s,” he said in a statement to FCUL about work done with cultures. bacterial cells that have been genetically engineered to express human proteins produced in the laboratory.

According to the study authors, this finding has implications for Alzheimer’s disease, given that “the onset of cognitive symptoms and dementia are associated with damage caused by aggregates of the tau protein and the spread of pathology to multiple areas of the brain.”

“This study reveals a new biological defense mechanism that is relevant in the early stages of the disease, which becomes ineffective over time due to the growing accumulation of toxic aggregates in the brain,” said Claudio Gomez, who told Luce that the “hypothesis” on which he “worked” his team, is that the protein “S100B” will perform protective functions against protein aggregation in the phase before the onset of symptoms of the disease, but in which “changes are already taking place in brain cells” (neurons) and “accumulation of deposits” of proteins “as part of early inflammatory response. “

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The researchers hope that understanding the functioning and protective action of proteins such as S100B will lead to the development of drugs with “therapeutic potential” that act in a similar way.

According to the OECD Health Outlook 2017 report, Alzheimer’s disease is the most common form of dementia that causes progressive and irreversible damage to certain cognitive functions. Portugal is the fourth country with the most diagnosed cases of dementia.

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Portuguese historical films will premiere on 29 December.



Portuguese historical films will premiere on 29 December.

Method Media Bermuda will present the documentary FABRIC: Portuguese History in Bermuda on Thursday, December 29 at the Underwater Research Institute of Bermuda.

A spokesperson said: “Method Media is proud to bring Bermuda Fabric: Portugal History to Bermuda for its 5th and 6th showing at the Bermuda Underwater Observatory. In November and December 2019, Cloth: A Portuguese Story in Bermuda had four sold-out screenings. Now that Bermuda has reopened after the pandemic, it’s time to bring the film back for at least two screenings.

“There are tickets For $ 20 – sessions at 15:30 and 18:00. Both screenings will be followed by a short Q&A session.

Director and producer Milton Raboso says, “FABRIC is a definitive account of the Portuguese community in Bermuda and its 151 years of history, but it also places Bermuda, Acors and Portugal in the world history and the events that have fueled those 151 years.

“It took more than 10 years to implement FABRIC. The film was supported by the Minister of Culture, the Government of the Azores and private donors.

Bermuda Media Method [MMB] Created in 2011 by producer Milton Raposo. MMB has created content for a wide range of clients: Bermuda’s new hospital renovation, reinsurance, travel campaigns, international sports and more. MMB pays special attention to artistic, cultural and historical content.

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Maestro de Braga is the first Portuguese in the National Symphony Orchestra of Cuba.



Maestro de Braga is the first Portuguese in the National Symphony Orchestra of Cuba.

Maestro Filipe Cunha, Artistic Director of the Philharmonic Orchestra of Braga, has been invited to conduct the Cuban National Symphony Orchestra, as announced today.

According to a statement sent by O MINHO, “he will be the first Portuguese conductor to conduct this orchestra in its entire history.”

In addition to this orchestra, the maestro will also work with the Lyceo Mozarteum de la Habana Symphony Orchestra.

The concerts will take place on 4 and 12 March 2023 at the National Theater of Cuba in Havana.

In the words of the maestro, quoted in the statement, “these will be very beautiful concerts with difficult but very complex pieces” and therefore he feels “very motivated”.

From the very beginning, Rachmaninoff’s Piano Concerto No. 2 will be performed by an Italian pianist (Luigi Borzillo), whom the maestro wants to bring to Portugal later this year. In the same concert, Mendelshon’s First Symphony will be performed.

Then, at the second concert, in the company of the Mexican clarinetist Angel Zedillo, he will perform the Louis Sfora Concerto No. 2. In this concert, the maestro also conducts Tchaikovsky’s Fifth Symphony.

“This is an international recognition of my work. An invitation that I accept with humility and great responsibility. I was surprised to learn that I would be the first Portuguese member of the Cuban National Symphony Orchestra. This is a very great honor,” the maestro said in a statement.

“I take with me the name of the city of Braga and Portugal with all the responsibility that goes with it, and I hope to do a good job there, leaving a good image and putting on great concerts. These will be very special concerts because, in addition to performing pieces that I love, especially Rachmaninov and Tchaikovsky, I will be directing two wonderful soloists who are also my friends. It will be very beautiful,” concludes Filipe Cunha.

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