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Portuguese Research Center Discovers Mechanism That May Explain Greater or Less Severity of Infection – The Observer

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Portuguese Research Center Discovers Mechanism That May Explain Greater or Less Severity of Infection - The Observer

Researchers at the Institute for Health Research and Innovation (i3S) have discovered a mechanism related to T cell alteration that may explain why SARS-CoV-2 infection causes mild to severe illness in humans.

In a statement from the Institute of the University of Porto on Wednesday, it was published that researchers had discovered a mechanism that “may explain why SARS-CoV-2 infection causes mild or even asymptomatic illness some people have severe and complex illnesses in others. “

The results of the study, funded by the Research 4 Covid Initiative of the Science and Technology Foundation (FCT), were published in the Journal of Immunology, and the article was noted as a “top reader” for the September issue.

A study by researcher Salome Pinho showed that circulating T cells “exchange their glycans.” [moléculas de açúcar] especially after infection with SARS-CoV-2 “and that this change “More pronounced” in asymptomatic people than in symptomatic people

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“Thus, an immunological response is determined based on glycosylated forms of T-lymphocytes, which provides protection against the virus,” the institute assured.

The alteration of the glycosylation profile in the immune response after infection with SARS-CoV-2 “appears to be caused by an inflammatory factor present in the plasma of the individuals.”

According to researcher Salome Pinho, this specific T-cell glycosignature, more pronounced in asymptomatic patients, “can be detected at diagnosis” and represents “A new biomarker of severity and prognosis of Covid-19, as well as a new therapeutic target”

In parallel, the research team demonstrated that asymptomatic patients have mononuclear blood cells exhibit “increased expression of a specific protein”capable of efficiently recognizing the virus and the level of expression of which in monocytes [células inflamatórias que pertencem à primeira linha de defesa] correlated with “better patient prognosis”.

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Also mentioned in the paper, Ines Alves and Manuel Vicente, the first authors of the study, say it is important to emphasize that this mechanism associated with SARS-CoV-2 infection “may be related to another type of respiratory viral infections that are opening up. new opportunities for the study of other infectious diseases ”.

The role of T lymphocytes in resolving or exacerbating Covid-19, as well as the ability to provide long-term protection against re-infection with SARS-CoV-2, “remains to be fully disclosed,” notes i3S.

The investigation looked to the cooperation of the University Hospital Center of Porto and the Hospital Center Vila Nova de Gaia / Espinho.

According to the latest report from Agence France-Presse, the Covid-19 pandemic has caused at least 4,234,618 deaths worldwide out of more than 198.8 million infections with the new coronavirus.

In Portugal, 17,397 people have died and 974,203 cases have been reported since the pandemic began in March 2020, according to the General Directorate of Health.

The respiratory illness is caused by the SARS-CoV-2 coronavirus, discovered in late 2019 in Wuhan, a city in central China, and currently variants identified in countries such as the UK, India, South Africa, Brazil and Peru.

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Portuguese health minister rejects conflict of interest over marriage to president

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The health minister said there was no conflict of interest in her marriage to the current chairman of the Order of Dietitians, saying that the trusteeship of that body had been delegated to the Secretary of State for Health Promotion.


Portugal Digital with Lusa



“Honestly, I don’t think it exists. I have no doubt that this Lady Secretary of State will fill this leadership role,” Manuel Pizarro said on Monday (age 26) on the sidelines of the Pharmacist’s Day celebrations in Sintra, in the Lisbon area.

Aware of the possible conflict of interest, Manuel Pizarro explained that he took “the most appropriate measure (…)”, which was to entrust the functions of guardianship of the Order of Nutritionists to Margarida Tavares.”

“(…) Since I took office as a minister, I have been aware that, since professional organizations have an administrative oversight role, (…) there is a risk of conflict of interest, and I have taken the measures that seem to me the most appropriate, which from the very decided at the outset that he would delegate this oversight function over the Order of Nutritionists to the Secretary of State for Health Promotion,” he stressed.

When asked about the reasons why Margarida Tavares’ name still does not appear in the Diário da República, the official said that “it was necessary to wait for the inauguration of the secretaries of state” and then “to organize the whole process of delegation of authority.” .

“It’s even a good chance that there is a Secretary of State for Health Promotion. I think custody of the Order of Dietitians has been well handed over to the Secretary of State for Health Promotion,” he repeated, noting that “he definitely won’t go through the Minister’s order.” [da Saúde]”.

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“If the secretary of state is responsible for this, it should not go through the minister,” he stressed.

Manuel Pizarro’s statements came after news that the government official may have a conflict of interest because he is married to the chairman of the Order of Dietitians, Alexandra Bento.

The Order of Dietitians was created in 2011 with the approval of the current Minister of Health, who at the time served as Secretary of State for Health.

In addition, Alexandra Bento was the only President of the Order of Occupational Health to attend the inauguration of Manuel Pizarro on 10 September.

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Portuguese newspaper criticizes CR7: “Less Ronaldo, more Portugal” | international football

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Portuguese newspaper criticizes CR7: "Less Ronaldo, more Portugal" |  international football

The cover of one of the most important sports newspapers in Portugal this Monday drew a critical tone against the greatest player in the history of the country.

+ See League of Nations table

On the eve of the day when the Portuguese national team will play with Spain and draw for reaching the semi-finals of the League of Nations, the daily newspaper “A Bola” printed a photo Cristiano Ronaldo stating that the player had lost influence in the team commanded by Fernando Santos.

“Less Ronaldo, more Portugal,” reads the headline.

The publication reports that the 37-year-old striker could start on the bench and lists some of the positives of his possible absence, such as the buffing of protagonist Bruno Fernandes. See below:

This Tuesday’s cover of A Bola is being printed by Cristiano Ronaldo – Photo: Reproduction

+ After shock and bleeding, Cristiano Ronaldo trains with a black eye in Portugal

Cristiano Ronaldo started and assisted in a 4–0 thrashing of the Czech Republic on the last round. He has only scored twice in his last eight caps, both against Switzerland.

Czech Republic 0 x 4 Portugal highlights in UEFA Nations League 2022

For Manchester United in the 2022/23 season, he started in three of the eight games played. In the last of them, against Sheriff from Moldova, in the Europa League, he scored for the first time.

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September, Holiday Month for the Deaf – Portuguese (Brazil)

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Mutirão Opens To Negotiation Of Individuals' Overdue Debts - Português (Brazil)

September is a very important and visible month for deaf people, with three dates that raise awareness and celebrate achievements that are part of the entire community’s trajectory and struggle. These are: – International Sign Language Day, September 23; – Day of the Deaf, 26 September; and Libra National Interpreter and Translator Day on September 30th. With a focus on the deaf community, the Department of Education is promoting several initiatives in this area.

The first is aimed at changing the scenario of educational and language policy based only on the inclusive perspective of including a deaf student in the school environment without guaranteeing procedures that enhance accessibility in his education. The National Guidelines for Bilingual Education for the Deaf integrate all stages of basic education and are based on the promotion of bilingual curricula and pedagogical practices for the deaf: Brazilian Sign Language (Libras) and written Portuguese.

Through the Department of Special Education, the MEC coordinates with interested municipalities the construction, renovation or expansion of bilingual schools for the deaf. To date, 11 locations in Brazil have shown interest in the project. To complement this phase, the Libras National Textbook Program (PNLD) provides accessible formats to deaf students and public school teachers of basic education in the country.

In the academic world, in partnership with universities, advanced training courses are offered for teachers, managers and professionals who want to work with bilingual education for the deaf. Thanks to the projects of various institutions, there are currently 3,520 vacancies for teaching the deaf.

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On the Internet, Canal Libras is a space for communication and content distribution with a focus on the national educational network, from early childhood education to higher education.

INES

Another important date: The National Institute for Education for the Deaf (Ines) turns 165 on the same Libra and the Deaf Day, September 26th. Within the structure of the Ministry of Education, the Institute stands out as a national reference in the field of deafness, necessary to support the formulation of public policies, and then for their implementation in the field. The Institute works to promote education for deaf children, youth and adults.

With information from Ministry of Education.

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