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Strange case of infection, 218 days under investigation in Brazil

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A group of Brazilian scientists are studying a case of infection with the new coronavirus that lasted at least 218 days – the period during which the virus replicated and even mutated.

According to the São Paulo State Foundation for Research Support (FAPESP), this is a 40-year-old man who, prior to contracting covid-19, underwent aggressive cancer treatment, as a result of which his immune system was severely weakened.

From September 2020 to April this year, the patient tested positive for the disease.

The study, published on the MedRxiv platform and which has not yet been reviewed by other experts, was conducted by scientists from the University of São Paulo (USP), who found that the virus is not only present in the patient’s body, but also replicating. during this period of time.

“Throughout this period, there was a risk of transmitting the infection to others,” explained Maria Mendes-Correa, a professor at the USP School of Medicine and the first author of the study.

The situation was confirmed by in vitro tests on weekly nasopharyngeal and saliva samples, in which an increase in viral load could be checked after a few hours.

“What The ability of the virus to replicate was monitored continuously and continuously. for 196 days in a row “out of 218 days of infection,” said Maria Mendes-Correa.

Blood, urine, and anal samples were also collected between January and April of this year, also indicating that SARS-CoV-2 persisted for most of the study period.

On the other hand, serological tests have shown that the patient has never developed antibodies

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In addition, scientists also detected mutations pathogen throughout the entire infectious process, from genetic sequencing of nasopharyngeal samples collected at 77, 134, 169 and 196 days after the onset of the first symptoms.

Some of these mutations occur in the spike protein, which the virus uses to enter human cells. “The data suggests that this evolutionary process of the virus” took place within the same host, whereas usually “these changes” are observed in the community, “said Maria Mendes-Correa.

“This is an alarming phenomenon as it promotes viral variants more adapted to the human body,” he added.

The patient in question spent most of his time in the hospital, and during the short periods when he stayed at home, he was also isolated.

Brazil is the Latin American country hardest hit by the new coronavirus pandemic, with 507,109 deaths and more than 18.1 million infections, the second most fatal disease in the world and the third most infected after the United States and India.

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30 km advance in Kherson and “significant victory” in Donbass. How did the last victories of the Ukrainian counter-offensive turn out?

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Follow all the news of the war live on the Observer.

The announcement of Russian partial mobilization, the formalization of the annexation of four Ukrainian territories and the threat of the Poseidon nuclear submarine. All these events of recent days show a stronger reaction from Russia and escalation of tension wars in Ukraine. However, almost nothing has changed on the ground since the beginning of September, and Moscow has failed to break Kyiv’s winning streak. Ukrainian troops keep reaching important successes in the counter-offensive in the south of the country and near Lugansk in the east.

It is increasingly likely that Kherson, one of the first cities captured by Russia at the start of the invasion, will soon be back under Ukrainian control. Moscow should not responsiveness strike back soon as the measures recently announced by Vladimir Putin are not yet in effect take a few months until they bring practical effect. For example, with regard to partial mobilization. Soldiers must be trained before they go to the front lines.

Ukraine wants to take advantage of this fact. To that end, he is following the same communications strategy as last month to catch Russian forces in error. The representative of the Ukrainian military from the southern region, Vladislav Nazaro, called for “silence”. “Don’t even report positive news about the actions of our units. Endurance and strength are the secret of our constant movement to victory”, these person in charge, quoted by El País. Paradoxically, Russia revealed the situation on the ground, namely the withdrawal of its troops and the advance of Ukrainian forces.

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The war in Ukraine has entered a dangerous phase of a terrible scenario at the nuclear level – Obozrevatel

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European Union (EU) diplomacy chief Josep Borrell said on Wednesday that the war in Ukraine caused by the Russian invasion is now “in a dangerous phase” due to a “terrible scenario” regarding Russian nuclear weapons.

The war continues, and the news from the battlefields is favorable for Ukraine. Ukraine is back on the offensive [mas] The war has entered a new phase, a phase that is undoubtedly dangerous because we are facing a frightening scenario that we must not turn a blind eye to,” said the High Representative of the Union for Foreign Affairs and Security Policy.

Speaking in a debate at the plenary session of the European Parliament in the French city of Strasbourg, Josep Borrell spoke of “a scenario of conventional war involving a nuclear power, a nuclear power that is now retreating from the usual scenario and that threatens to use nuclear weapons.”

“This is certainly a worrying scenario in which we must show that our support for Ukraine is unwavering,” he stressed.

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Despite emphasizing that “Ukraine is advancing on three fronts, in the Donbass, […]in the southern center of Zaporizhia, advancing on Mariupol, and finally on Kherson,” the head of public diplomacy pointed out that Russia “still has a superiority in numbers, superiority in firepower,” so caution is needed.

Earlier today, EU member states reached a political agreement on new sanctions against Russia for invading Ukraine, the eighth package, due to come into effect on Thursday as a “strong response” to the annexation of Ukrainian territories.

Proposed by the European Commission last Wednesday, amid Russia’s “new escalation” with “fraudulent referendums”, partial mobilizations and the threat of nuclear weapons, a new package of EU sanctions includes a ceiling on Russian oil prices, new trade restrictions, depriving Russia of about 7 billion euros revenues, a ban on the export of more products to deprive the Kremlin of key technologies for the Russian military machine, and an update to the list of individuals and entities subject to restrictive measures. .

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In particular, the EU added pro-Russian officials in the Russian-occupied Donetsk, Luhansk, Kherson and Zaporozhye regions to the list of individual sanctions.

In recent days, there have even been Russian attacks on the area of ​​the Zaporozhye nuclear power plant in southern Ukraine, the largest in Europe, after Russian President Vladimir Putin announced a partial mobilization of 300,000 Russian reservists.

“The position of the Russian army is very bad. Including because the Russian soldiers do not know what the war is for, and those 300,000 who will be taken from their native places to the front will understand even less, so the war can be won on the battlefield, but it must be won. in the realm of ideas. In addition to the war itself, there is another war – the war for the supremacy of values, ”said Josep Borrell.

And at a time when there are fears of interruptions in Russian gas supplies to the EU, the head of EU diplomacy stressed that Russian President Vladimir Putin “waits for cold weather, interruptions in gas supplies, high prices and low temperatures in order to undermine the European will and will continue to support Ukraine”.

“Here we need to ask the Europeans to understand what is at stake, because our support for Ukraine is not just a matter of generosity, our support for Ukraine must be unwavering, because the security of Ukraine is inextricably linked to our own security,” he added.

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Ukraine: war has entered ‘dangerous phase’, head of European diplomat warns

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“The war continues, and the news from the battlefield is favorable for Ukraine. Ukraine is back on the offensive [mas] The war has entered a new phase, a phase that is undoubtedly dangerous because we are facing a frightening scenario that we must not turn a blind eye to,” said the High Representative of the Union for Foreign Affairs and Security Policy.

Speaking in a debate at the plenary session of the European Parliament in the French city of Strasbourg, Josep Borrell spoke of “a scenario of conventional war involving a nuclear power, a nuclear power that is now retreating from the usual scenario and that threatens to use nuclear weapons.”

“This is certainly a worrying scenario in which we must show that our support for Ukraine is unwavering,” he stressed.

Despite emphasizing that “Ukraine is advancing on three fronts, in the Donbass, […]in the southern center of Zaporizhia, advancing on Mariupol, and finally on Kherson,” the head of public diplomacy pointed out that Russia “still has a superiority in numbers, superiority in firepower,” so caution is needed.

Earlier today, EU member states reached a political agreement on new sanctions against Russia for invading Ukraine, the eighth package, due to come into effect on Thursday as a “strong response” to the annexation of Ukrainian territories.

Proposed by the European Commission last Wednesday, amid Russia’s “new escalation” with “fraudulent referendums”, partial mobilizations and the threat of nuclear weapons, a new package of EU sanctions includes a ceiling on Russian oil prices, new trade restrictions, depriving Russia of about 7 billion euros revenues, a ban on the export of more products to deprive the Kremlin of key technologies for the Russian military machine, and an update to the list of individuals and entities subject to restrictive measures. .

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In particular, the EU added to the list of individual sanctions pro-Russian officials in the Russian-occupied Donetsk, Luhansk, Kherson and Zaporozhye regions of Ukraine.

In recent days, there have even been Russian attacks on the area of ​​the Zaporozhye nuclear power plant in southern Ukraine, the largest in Europe, after Russian President Vladimir Putin announced a partial mobilization of 300,000 Russian reservists.

“The position of the Russian army is very bad. Including because the Russian soldiers do not know what the war is for, and those 300,000 who will be taken from their native places to the front will understand even less, so the war can be won on the battlefield, but it must be won. in the realm of ideas. In addition to the war itself, there is another war – the war for the supremacy of values, ”said Josep Borrell.

And at a time when there are fears of interruptions in Russian gas supplies to the EU, the head of EU diplomacy stressed that Russian President Vladimir Putin “waits for cold weather, interruptions in gas supplies, high prices and low temperatures in order to undermine the European will and will continue to support Ukraine”.

“Here we need to ask the Europeans to understand what is at stake, because our support for Ukraine is not just a matter of generosity, our support for Ukraine must be unwavering, because the security of Ukraine is inextricably linked to our own security,” he added.

Russia invaded Ukraine on February 24th.

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