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Europe, United kingdom strike vaccine offers antibody therapies on the rise

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Jess O'Hara a research technician works on the process of testing antibodies to see if they bind to the virus, in the laboratory at Imperial College in London, Thursday, July 30, 2020. Imperial College is working on the development of a COVID-19 vaccine. Scientists at Imperial College London say they are immunizing hundreds of people with an experimental coronavirus vaccine in an early trial after seeing no worrying safety problems in those vaccinated so far. Dr. Robin Shattock told the Associated Press that he and colleagues had just finished a very slow and arduous process of testing the vaccine at a low dose in a small number of participants and would now be expanding the trial to about 300 people, including those over 75. (AP Photo/Kirsty Wigglesworth)

A few of the frontrunners in the worldwide coronavirus vaccine race declared Friday bargains for hundreds of tens of millions of doses with European nations around the world, which will add to the demand from customers on an now strained offer chain as the worldwide pandemic rages on.

Johnson and Johnson (JNJ) struck a deal for 30 million doses with the U.K. and is collaborating on a Stage 3 demo. The business is also in talks with the European Union to provide 200 million doses. In the meantime, AstraZeneca (AZN) announced a offer for 400 million doses, and Novavax (NVAX) struck a deal for 60 million doses with the U.K. that also includes collaboration on a Phase 3 trial.

By comparison, these similar providers have promised 100 million doses (J&J and Novavax, each individual) and 300 million doses (AstraZeneca) to the U.S. All are in many stages of medical trials, with AstraZeneca major with its partnership with Oxford College.

A great deal of the concentrate of vaccine distribution has been on the created West, even though concerns about the effects on very low- and center-revenue nations around the world linger.

The Entire world Overall health Business (WHO), Bill and Melinda Gates Basis and the world-wide vaccine alliance, GAVI, are all concentrated on the difficulty. The Serum Institute of India has been a dominating dealmaker, with commitments to create Oxford University’s vaccine candidate as properly as Novavax, and has also partnered with the Gates Basis to produce less expensive vaccines.

The world wide circumstance count is on the cusp of surpassing 21 million this week, with extra than 760,000 lifeless. In the U.S., far more than 5.2 million have been influenced, and much more than 167,000 have died from the coronavirus.

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When hopes are pinned on the vaccine to end the global pandemic, Nationwide Institute of Wellness director Francis Collins reported Thursday that no final decision on a vaccine acceptance is probable by the fall, countering the statements of President Donald Trump, who is pushing for a vaccine to be ready in advance of the election in November.

In the meantime, CureVac (CVAC) announced its IPO selling price at $16 Friday, even as the stock was established to open at $45 for every share. Vaccine enthusiasm has boosted compact biotechs this 12 months, this sort of as Moderna (MRNA) and Novavax, prompting issues about in excess of-valuation of corporations facing potent opposition for their opportunity initially-at any time products on the sector.

Antibody treatment options, at property

Expanding momentum and optimism about the likely of antibody therapies — seen as a bridge until eventually vaccines are available— carries with it some of the exact same affordability and accessibility considerations as vaccines. It’s why just one firm is targeted on a likely topical antibody treatment.

American BioDefense Institute government director Ravi Starzl explained to Yahoo Finance an at-residence remedy would get rid of lots of accessibility obstacles, shifting the cost from hundreds or countless numbers of bucks to — potentially— a lot less than $100 for every thirty day period, without having insurance policies coverage.

“Antibodies are the vital to fixing this pandemic,” Starzl stated, noting that convalescent plasma, monoclonal antibodies and vaccines all have that crucial ingredient in common.

Jess O’Hara a analysis technician performs on the procedure of testing antibodies to see if they bind to the virus, in the laboratory at Imperial College or university in London, Thursday, July 30, 2020. Imperial Higher education is operating on the enhancement of a COVID-19 vaccine. Experts at Imperial College or university London say they are immunizing hundreds of persons with an experimental coronavirus vaccine in an early demo following viewing no stressing basic safety complications in people vaccinated so much. Dr. Robin Shattock instructed the Involved Push that he and colleagues had just finished a really gradual and arduous course of action of screening the vaccine at a reduced dose in a little amount of participants and would now be increasing the demo to about 300 people today, like all those over 75. (AP Photo/Kirsty Wigglesworth)

But with monoclonal antibodies and convalescent plasma, the will need for professional medical professionals in a overall health treatment method, and the value that goes with all of it, are limitations to accessibility.

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The company is on the lookout at avian antibodies as a way to suppress the virus with apps in the nasal and throat passages — where by the virus is regarded to enter the body— and act as “passive immunity,” Starzl mentioned.

The creation of these at-house kits would be a lot cheaper to develop and to apply, he mentioned. But the whole selection of kits will also determine the good results of any this sort of probable product. At very best, some of the biggest monoclonal antibody factories can create 400,000 solutions per thirty day period.

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Economy

Portugal Could Become a Reshoring Hub in Europe According to New Report – Executive Digest

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Portugal Could Become a Reshoring Hub in Europe According to New Report - Executive Digest

European companies are looking in the EMEA region (which covers Europe, the Middle East and Africa) for an alternative to manufacturing and sourcing in Ukraine and Asia after months of supply chain disruptions, according to a new Supply Chain Disruptions report sponsored by JLL.

According to this report, there are several companies operating in the retail and manufacturing sectors that have already decided to partially or completely redistribute their production, and the data shows that the new European beneficiaries of the “reorientation” are Central Europe and Romania, and the European borders with Turkey and Morocco are also on the radar.

This trend follows a pandemic that has caused disruption in distribution networks and serious problems in ports and airports, so companies have begun to choose “reshoring” as an attempt to solve the problem of disruption in supply chains.

JLL also expects that the shortage of land and labor will boost demand in Central Europe, from the primary market to the secondary and tertiary markets, the latter strategically located.

Data from Flexport (a global logistics platform) shows that the average container flight from Asia to Europe has almost doubled since 2019, and Buck Consultants International (BCI) research confirms the same as JLL: more than 60% of US and European companies plan to send part of their products back to their country of origin.

Given the existing transport networks and logistics gateways, it can be said that goods will circulate primarily along two distribution corridors: the traditional European dorsal (from central England to northern Italy) and the emerging “Black Sea banana” connecting Budapest. to the Black Sea.

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Marlene Tavares, Head of Retail Investment and Logistics at JLL, explains: “The discussion about nearshoring (where operations move to a country close to the country of origin, as opposed to offshoring) is not new. Rising wages in places with low-cost production and increased risk from climate change, strikes and accidents such as the blockade of the Suez Canal have sparked controversy over the issue over the past decade.

However, a more favorable cost-risk ratio and the loss of many manufacturing infrastructures in Europe continued to give the Asian continent an advantage in hosting large distribution centers and manufacturing a wide range of products. This scenario is now changing due to the recent situation as well as new consumption habits. In this context, Portugal has a competitive advantage due to its very attractive geographic location and demographics, which place us prominently in the European Neighborhood Strategy,” he emphasizes.

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Emirates increases total number of huge Airbus A380 flights to London to no less than 9

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Emirates increases total number of huge Airbus A380 flights to London to no less than 9


Airbus A380 – Image: Emirates


Emirates announces this Monday, December 5th that it has stepped up its operations at Gatwick Airport, one of the terminals serving London, England, by adding a third daily flight on a large Airbus A380 double-decker aircraft.

The additional operation will offer more than 1,000 seats on the Dubai-Gatwick line every day of the week. Emirates flight EK11 departs Dubai at 02:50, flight EK15 at 07:40 and flight EK09 at 14:25.

In addition to the company’s services at Heathrow Airport, which has six A380s a day, the connection between Dubai and London now has an incredible 9 flights a day on the world’s largest passenger transport aircraft.

Emirates currently serves the UK with 119 weekly flights from seven hubs, including: London Heathrow Airport (A380) six times a day; three times a day to London Gatwick (A380); daily service to London Stansted (B777); three times a day to Manchester (A380); dual daily service to Birmingham (B777); daily flights to Newcastle (B777); and a daily service to Glasgow (B777).

According to Emirates






With a degree in mechanical engineering and postgraduate studies in aircraft maintenance, he has more than 6 years of experience in the field of technical control of aircraft maintenance.


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Socrates, Granadeiro and Bava demand compensation for bad faith litigation from Espírito Santo International

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José Socrates, Enrique Granadeiro and Zeynal Bava are demanding compensation for what is left of the assets of Espírito Santo International (ESI). The Central Civil Court of Lisbon, in which three defendants and five defendants, including Ricardo Salgado, are suspected of causing more than 72 million euros in damage to the GES universe.

Challenging this charge, in addition to a plea of ​​not guilty, the three are asking the court to sentence the insolvent property complex “to pay compensation for the recovery of all costs and restitution for all losses caused by this form of litigation,” the defense stressed. former Prime Minister of the Socialists.

The bankruptcy filing states that since at least 2007, the defendants have been paid “large sums” that turned out to be “illegal and unreasonable counterparties” in defense of the interests of GES, “namely, in the strategy laid out by Ricardo Salgado in defense of the interests of the group in PT ”, but also in the mission to “put an end to the participation of the PT group in the share capital of the operator VIVO” – Luxembourg masters Alain Rukavina and Paul Laplum, managers of insolvent property and authors The process said that this money was transferred “to the detriment of the assets” of ESI and the Group’s offshore companies HPS.

As for the administrators of insolvent property, Granadeiro and Bava were to be paid “for their work contrary to their professional duties and interests of the PT in their positions of authority”, and Socrates, as prime minister, would receive money from the government. Espírito Santo Group “to act in accordance with the strategies identified by Ricardo Salgado for PT to the detriment of the public interest.”

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